【摘要】 优降宁和利血平联合应用对不同种属动物的血压产生不同的效果。在优降宁预先作用基础上给予利血平,或二药同时给予,都使麻醉犬的血压明显上升,出现利血平作用的翻转。在同样条件下,二药对正常大鼠及原发性高血压大鼠均呈现协同作用,使血压明显下降;在大鼠,二药联合应用均不出现利血平作用的翻转。更多还原

【Abstract】 The combination use of pargyline and reserpine produced different effects on blood pressure of different animal species. Reserpine administered after pretreatment or concurrently with pargyline caused a significant increase in blood pressure of the anesthetized dogs. However, there was an evident synergism in hypotensive effect after the combination use of these two drugs under the same conditions in normotensive and spontaneous hypertensive rats and there was no reversal of action of reserpine on blood pressure after combination use with pargyline in such animal species.更多还原