【摘要】 本文进一步研究了芳胺与取代苄叉丙酮的曼尼希（Mannich）反应,合成了9个Mannich碱（Ⅰ）.同时用醛胺缩合法合成了具有药理活性的吗啡啉和取代苄叉丙酮的Mannich碱（Ⅴ）,提高了合成产率.当苄叉丙酮的取代基R=4-CH₃O,3,4-OCH₂O时,有时有酮胺缩合产物——Schiff碱（Ⅳ）生成,只是反应温度有所不同.对Ⅳ的生成机理、结构及合成进行了讨论.更多还原

【Abstract】 Further studies of Mannich reaction of arylamine, substituted benzyliden- cacetone and formaldehyde are carried out. Nine kinds of Mannich Base（Ⅰ） （RC₆H₄CH=CHCOCH₂CH₂NHAr, R=4-NO₂, 4-Cl, 3, 4-OCH₂O） are synthesized. Four such Base （Ⅴ）（RC₆H₄CH=CHCOCH₂CH₂NC₄H₈O·HCI R=H, 4-OCH₃, 4-NO₂, 4-Cl） having pharmacological actions are also synthesized and their yields are improved. When R is methoxy, methylenedioxy, the condensation product of arylamine and substituted benzylideneacetone-Scbiff Base（Ⅳ）（RC₆ H₄CH=CHC（CH₃）=NAr, R=4-OCH₃, 3,4=OCH₂O） are also formed at the same time, but under different temperatures. Their formation mechanism, structure and synthesis are discussed.更多还原