【摘要】 <正> 研究肝炎和肝癌关系的实验动物中,唯有土拨鼠感染土拨鼠肝类病毒(WoodchuckHepatitis Virus,WHv)后,其病程、结局与人类感染乙型肝炎病毒(HBV)相似,WHV DNA可与宿主肝细胞DNA整合并产生肝癌。中国旱獭(Marmota marmota)在更多还原

【Abstract】 Fourteen young Chinese marmots ( Marmota bobak sibirica Radde ) were randomly allocated into two groups of 7 each. Standard challenge pool prepared from sera of woodchucks infected with woodchuck hepatitis virus (WHV) and negative control pool were inoculated into the two groups respectively. WHsAg, anti-WHs were detected by RIA in the serum of one of the animals challenged with the standard pool. WHsAg particles of both spherical and filamentous forms and WHV virions were found in its serum under electromicroscope. These results suggest that young Chinese marmots may be sensitive to WHV.更多还原