【摘要】 491份宫颈拭子病毒分离结果表明:糜烂宫颈单纯疱疹病毒(HSV)分离阳性率(30.8％)是正常宫颈(2.6％)的11.8倍,用人干扰素治疗一个疗程后,病毒分离率下降至疗前的1/4.36例糜烂宫颈活体组织DNA分子杂交表明,乳头瘤病毒16型(HPV-16)阳性者占52.8和,HPV-18占17.9％,HPV-6B占28.1％,HPV-11占7.7％,251例宫颈糜烂患者经人(?)D型基因工程干扰素双盲对比治疗后,总有效率达93.8％,显效率达60％,分析临床疗效与HSV分离率的变化表明,临床有效病例中有35％(49/140)在治疗后病毒阴转,有57％在疗前疗后均未分离出HSV,有5％在疗前疗后保持阳性不变,有2.9％疗前阴性,疗后阳性,上述结果表明,HSV和HPV与慢性宫颈炎有一定关系。更多还原

【Abstract】 Result obtained from virus isolation using rabbit kidney cell culture from 491 cervical swabs indicated that the herpes simplex virus (HSV ) isolation rate from erosive cervix ( 30.8%) was 11.8 times higher than that from normal cervix (2.6%) . After one course of human recombinant interferon αD treatment, the HSV isolation rate markedly dropped down to 1/4 of that before treatment. 36 DNA samples isolated from tissues taken from erosive cervices were hybridized with 〔α32P〕labelled pHPVs ( human papilo-ma virus clones), among them 19 cases are HPV-16 positive ( 52.8% ), 5 cases are HPV-18 positive ( 17.9% ) ,9 cases are HPV-6B positive( 28.1% ) and only 2 cases are HPV-11 positive ( 7.7% ) .A double blind controlled study on the efficacy of human rIFN-aD in the local treatment of 251 cases with typically cervical erosion was carried out. 93.8% cases appeared clinically improved and 60% markedly improved. Analysing the relationship between clinical efficacy and HSV isolation rate, it was demonstrated that 35% of clinically improved cases converted to virus negative after treatment, 57% were negative unchanged before and after treatment and 5% remained positive after treatment, only 2.9% who were originally negative became positive after treatment. The above-mentioned results suggest that HSV and HPV are closely related to the pathogenesis of cervical erosion.更多还原