【摘要】 测定了55例癫痫患者头发锌、铜含量。发铜含量(6.5±2.1μg/g)显著低于正常对照组(10.6±5.6μg/g),P<0.001;女性患者发锌含量(170.1±56.9μg/g)低于正常对照组(224.2±58.4μg/g),P<0.05;癫痫患者发锌、铜比值(26.6±10.3)较对照组(20.9±11.4)曾高,P<0.05。取样前一年内有癫痫发作,病程为0～5年,癫痫大发作型,脑电图重度或中度异常者,发锌含量降低,与对照组相比有明显差异(P<0.05);抗癫痫药物对发锌影响较对发铜为大。发锌、铜含量及锌、铜比值增高,似表明抗癫痫治疗效果较好。以上结果提示癫痫患者的发锌、铜代谢有异常,其变化与血浆锌、铜含量改变不同。更多还原

【Abstract】 The concentration of zinc and copper in the hair of 55 patients withepilepsy was determined and its relationship with the clinica1 manifestationswas studied. The hair copper (6.5±0.1μg/g X±SD) levels in patients withepilepsy were significantly lower than those in the nomal control group(10.6±5.9μg/g), P<0.001. The hair zinc (170.1±56.9μg/g) levels in femalepatients were significantly lower than those in the nomal control group(224.2±58.4μ/g ), P<0.05. In patients with a course of 5 years who recentlyhad epileptic attacks in the from of generalized seizure and whose EEGshowed heavy or middle abnormality, the hair zinc levels were reduced, ascompared with those in nomal controls. Antiepileptic drugs had more effecton hair zinc than on copper. An increase in the hair zinc and copper and agreater ratio of zinc to copper might demonstrate the efficiency of the drugs.These findings suggest that patients with epilepsy might have an abnormalhair zinc and copper metabolism, with a change in concentration differentfrom that in the plasma.更多还原