【摘要】 本文以临床细胞学确诊“肺癌”的10例患者胸积液为材料,制备染色体进行分析观察。在检查565个癌积液细胞的染色体中,发现染色体数目分布范围广,结构异常的数量较多及标记染色体的出现等,这些变化均符合恶性肿瘤细胞遗传学特征。在10个标记染色体中,其中6个的组成与1号染色体的断裂重排有密切关系:这与肺癌实体瘤染色体变化相似,因此我们认为1号染色体、特别是1q²¹和1p¹¹的断裂与肺癌的发生可能存在一定关系。更多还原

【Abstract】 565 chromosome metaphases derived from pleural fluid of 10 patients withlung cancer have been studied. Varieties of chromosomal number and strueture were found at each case. The chromosomal number varied in a wide range from 39 to 200. Abnomality of structure and marker chromosomes also can be found. (These changes were consistent with cytogenctic character of malignant tumors. ) There are 10 markers, 5 of which were associated with chromosome 1 and the breakpoints located in P11, q21 or near centric area . These results were similar to that obtained from lung cancer. We suggest that breakpoints at chromosome Iq21 and IP 11 may play a key role on the tumorigenesis of the lung cancer.更多还原