【摘要】 本文对河北地区598例恶性肿瘤患者及310名健康人进行了结合珠蛋白（HP）表型及HP¹基因频率的测定。发现食管癌和肝癌患者的HP^2-1表型频率明显地偏高,而其它癌患组的HP^2-1表型与正常对照组间无明显差异。肝癌、大肠癌和肺癌患者的HP¹基因频率非常显著地高于正常人群组,而食道、贲门癌、胃癌,宫颈癌和乳腺癌组的HP¹基因频率与正常对照组间无差异。 结果提示河北地区HP¹基因似与大肠癌、肝癌和肺癌的发生有关。更多还原

【Abstract】 The frequency of Haptoglobin (HP) phenotypes and HP gene were determined in 598 patients with cancer and 310 healthy controls in Hebein Province. An increased frequency of Hp2-1 phenotypes was found in esophageal cancer and hepatocarcinoma. An unsignifi-cantly changed frequency of HP2- 1 was observed in other groups of patients with cancer. The frequency of HP1 allele was more signifcantly increased in the patients with hepatocarcinoma, cancer of the large intestine and lung cancer, but the frequency of HP1 alleie was unsignificantly increase in patients with esophageal carcinoma and cancer of the cardia, gastric cancer, cervical carcinoma and breast cancer.The results suggested a relationship between HP1 alleie and the cancer of large intestine, hepatocarcinoma and lung cancer in this area.更多还原