【摘要】 <正> 阿克拉霉素B是一种新型蒽环类抗肿瘤抗生素阿克拉霉素A的同系物,对小鼠白血病L-1210、P-388S-180及Lewis肺癌有抑制作用。已有文章对其毒性、在动物血液中浓度的动态变化以及体内代谢及作用机制等进行了研究。为深入研究其作用原理,我们观察了阿克拉霉素B对人早幼粒白血病细胞的分化诱导作用。更多还原

【Abstract】 Aclacinomycin-B(ACM-B) is a derivative of Aclacinomycin-A. Experiments on animals showed that it exhibited inhibitory effect on Leukemia L-1210, P-388, sarcoma 180 anl Lewis lung carcinoma. In order to explore the mechanism of action of ACM-B,the differentiation of HL-60 cells induced by this compound is studied. Studies demonstrated that HL-60 cells could be induced to differentiate into more or less mature cells by ACM-B in terms of functional and mo-rphorlogical characteristics. After a treatment with 10-1μg/ml of ACM-B for 6 days, the NBT positive cells were increased to 87% and myelocytes and met-amyelocytes amounted to 67%. It seems that ACM-B inhibits the proliferation of HL-60 cells. In comparision with retinoic acid, the advent of morphological and functional changes of the HL-60 cells induced by ACM-B was later than by retinoic acid . It may imply of a different mechanism of induction between them.更多还原