【摘要】 本文报告38例肺癌,光镜下属小细胞癌4例,鳞癌11例,腺癌23例。电镜下见小细胞癌4例中3例(属燕麦细胞型)见到神经分泌颗粒,另一例(属中间细胞型)未见到。作者认为小细胞癌为异源性来源,故要区别有分泌颗粒与无分泌颗粒的小细胞癌,从而观察其生物学特性及治疗,预后的差异。鳞癌细胞可分为成熟型与未成熟型,后者相当于介乎鳞状及柱状分化的双相分化的鳞癌细胞。从肺腺癌电镜下细胞形态可分为粘液细胞型,Clara细胞型,Ⅱ型肺胞上皮细胞型,不具分泌颗粒腺细胞型及混合细胞型五型。本文对肺腺癌的来源及其超微结构特征进行了讨论,认为肺腺癌也是异源性的。更多还原

【Abstract】 The ultrastructural study on 33 cases of pulmonary carcinoma, including 4 cases of small cell carcinoma, 11 cases of squamous cell carcinoma and 23 cases of adenocarcinoma classified by light microscopy, was reported. Neurosecretory granules were found in 3 (oat-cell type) of 4 cases and not in the one other case (intermediate type) of small cell carcinoma. Therefore, we consider that the small cell carcinoma belongs to the heterogeneous tumor and that subclassification of small cell carcinoma into secretory granular and non-secretory granular types seems necessary for evaluation of the biologic behaviors and for prediction the therapeutic effect and prognosis. Tumor cells of squamous cell carcinoma could be divided into two types: mature type and immature type, whereas the cell of the latter type is classified by its biphasic differentiation, situiating between squamous cell and columnar cell differentiation. For adenocarcinoma, five types of cell, including mucous cell, Clara cell, Type Ⅱ pneumocyte, non-granular cell and mixed cell, could be identified by electron microscopy. The histogenesis and ultrastructurel features of pulmonary adenocarcinoma were under discussion and the authors believed that the pulmonary adenocarcinoma is also of heterogeneous tumor.更多还原