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利凡诺甘油丙二醇溶液对肝肾损害的观察

THE STUDY OF MIXTURE OF RIVANOL,GLYCEROL,AND PROPYLENE GLY COL ON LIVER AND KIDNEY

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【作者】 周远大; 郑明祺; 刘银君; 沈际焜;

【Author】 Department of pharmacology Zhou yuanda Department of pathology Shen jikun

【机构】 重庆医科大学药理教研室; 重庆医科大学病理教研室;

【摘要】 两种利凡诺(40mg/kg)制剂(“水剂”和“合剂”)雌兔腹腔注射,72h后的SGPT和BUN与用药前比较,均无显著差异(P>0.05);肝肾组织亦无明显病理改变。腹腔内大剂量利凡诺并不明显引起肝肾功能和形态损害。如利凡诺“合剂”用于宫腔内抗早孕时,即使利凡诺完全进入腹腔内也还是安全的

【Abstract】 Both rivanol solution and the mixture of rivanol, glycerol, and propylene glycol were injected into the peritoneal cavities of the female rabbits. There were not significant difference on SGPT and BuN in the rabbits before and after given both rivanol preparations (40mg/kg). The livers and kidneies didn’t occur significantly pathological change than control. Rivanol intraperitoneal injection may not impair the liver and kidney. When intrauterine rivanol used for termination of early pregnancy enters peritoneal cavity, it may not impair the liver and kidney. The termination of early pregnancy with mixture of rivanol, glycerol,and propylene glycol is safe

【关键词】 利凡诺; 家兔; 肝; 肾;
【Key words】 rivanol; rabbit; liver; kidney;
  • 【文献出处】 重庆医科大学学报 ,Journal of Chongqing Medical University , 编辑部邮箱 ,1986年04期
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