【摘要】 本文采用D—氨基半乳糖形成的急性肝功能衰竭模型大鼠,观察云芝胞内多糖-Ⅱ注射剂对肝损害病变过程的影响。 结果表明注射该药物(50mg/d连续 3天)后,印度墨汁清除率K值在健康动物有明显提高(0.0393 ± 0.0086比注射前0.0259±0.0055,P<0.005)。在D—氨基半乳糖形成的肝损害大鼠K值也有明显提高(0.0227±0.0049增高到0.0359±0.00624,P<0.001),而在对照组K值虽亦有所增高,但在统计学上未见明显差异(P>0.05)。说明该品能使RES功能增强。实验组的SGPT与对照比较有明显减轻(SGPT 342±313比690±296μ/dl,p<0.005),存活率有明显提高(8/12只即66.7％比1/12只即8.3％,p<0.01)。结果证明该产品可增强RES功能,使D-氨基半乳糖诱致肝损害减轻和存活率明显增高。其作用机制或与内毒素血症的明显改善有关。更多还原

【Abstract】 The effect of Polysaccharide of Polystic-tus versicolor-Ⅱ on GalN-induced liver damage model rats had been investigated. Results showed that after three consecutive days in jections(50mg/kd I.P.per day),the K value oi Indian Ink clearance rose from 0.0227±0.0049 to 0.03o9± 0.00624, P<0.001 in the experimental group, while there was no statistical significant difference in the control(p<0.05). The serum level of SGPT elevated in a lesser degree (342 ± 313u / dl)and the survival rate augmented(8 / 12 rats, 66.7%)as compared to that of the control (690 ±296 u / dl and 1/12 rats,8.3%respectively).The results indicated that the Polysaccharide could enhace the RES function, alleviated the degree of liver damage ahd improved the survival rate of the GalN induced liver damage rats. It suggested that the mechanism of the effect may be related to the improvement of endotoxemia of ths model rats.更多还原