【摘要】 <正> 近年来,由于厌氧培养技术的进步,厌氧菌感染已受到临床各科的重视。人体某些部位如肠道、口腔、女性生殖系统的厌氧菌感染率尤高,有的甚至可达70～90％。许多厌氧菌尤其是临床上最常见的脆弱拟杆菌对常用的抗生素如氨基糖苷类、青霉素类以及某些头孢菌素的耐药率很高。为配合临床合理选择抗生素,提高疗效,我室采用微量稀释法技术,测定了15种半合成抗生素及2种其他抗菌药物对49株临床分离厌氧菌的体外抗菌活性。现总结如下,供临床参考。更多还原

【Abstract】 The susceptibility of 49 clinically isolated anaerobic bacteria to 15 semisynthtic antimicrobial agents and 2 other antimicrobial drugs was determnied by microdilution tec-hniqueAll drugs with the exception of azthre-onam, showed fairly strong antimicrobial activities against Peptococcus and Peptostr-eptoccus(9)with MIC<0.06μg/ml.Fusobacterium (2), Propionic Bncterium (4), Cl. tetani(1), Cl. sordellii (1) and Cl, perfringes(3) were very susceptible to most drugs tested. However, Cl. diffile (1) and Cl. sphenoides( 1) were resistant to some drugs.Metronidazole, closely followed by cli-ndamycin rifampicin, rifadin.rifapentin, ch-loramphenicol and N-formimdoyl thienam-ycin(lmipenem)exhibited strong antibacterial activity against B. fsagillis( 27 )with MIC90 ≤8 μg/ml . 50% of B. fragillis tested were inhibited by moxalactam. cefotaxime, cefo-perazone, piperacillin and carbenicillin at clinically obtainable blood level.更多还原