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微生物产生的酶抑制剂研究 Ⅵ.S-038菌株产生的抑胃酶剂提取纯化和鉴别
SEPARATION PURIFICATION AND IDENTIFICATION OF PEPSIN INHIBITOR PRODUCED BY S-038
【摘要】 S-038抑胃酶剂是福东链霉菌S-038菌株产生的。经正丁醇萃取、硅胶柱层析分离得到并经过DEAE-52纤维素和Sephedex G-15层析纯化。通过理化性质、紫外光谱、红外光谱、氨基酸分析,高压液相色谱以及质谱等的研究,认为其主要组分与Pepstatin A同质。
【Abstract】 S-038 pepsin inhibitor is produced by a Streptomyces fudongus n. sp. Liu. It is isolated by n-butanol extract and silica gel colum chromatography, and puripied by DEAE-52 cellulose and Sephedex G-15chromatography. From their physico-chemical properties, UV、 IR、 HPLC、 AA and MS spectrum,the major component of S-038 pepsin inhibitor is considered to be identical to pepstatin A.
- 【文献出处】 抗生素 , 编辑部邮箱 ,1986年03期
- 【被引频次】3
- 【下载频次】39