【摘要】 用中国预防医学科学院寄生虫病研究所合成的抗阿米巴新药甲硝磺酰咪唑对体外培养的两株溶组织内阿米巴作用测定,表明该药与滋养体培养72小时,其致死浓度为512μg/ml,即100％虫体死亡,在64～256μg/ml浓度时,均有一定程度的抑制作用,至32μg/ml时,对虫体无影响。与甲硝咪唑对比,作用相仿,值得临床试用。更多还原

【Abstract】 The amoebicidal activity of a range of concentrations of tinidazole (fasigyn) synthesized by the Institute of Parasitic Diseases, Chinese APM was determined on the in vitro cultures of Entamoeba histolytica (T and B strains) in a diphasic LAS medium.The results indicated that after 72 hours’ incubation tinidazole was 100% lethal at 512μg/ml, at which both T and B strains of E. histolytica trophozoites were killed. At the concentration of 64-256μg/ml, the growth of trophozoites was inhibited to a certain extent. The results obtained compared well with those obtained with metronidazole. It is suggested that tinidazole might be used for clinical trial.更多还原