【摘要】 用显微图象测量仪对不育男性、正常男性和大Y家系男性共220例作了Y染色体C带异态性定量分析和比较研究。结果:120例不育男性和80例正常男性Yqh/16p 5个等级类型及出现频率均无显著差异,众数皆为第3级;第4级和第5级的Yqh+分别为15.83%和17.50%。20例大Y家系男性Yqh/16p测量结果均为Yqh+(第4级和第5级),除先证者外,都能正常生育。Yqh+频率高低与睾丸大小、无精、少精无正相关,Yqh+频率在核型异常和正常间无显著差异,表明Yqh+(大Y)与男性不育并不明显相关。更多还原

【Abstract】 To detect the relationship between large Y chromosome(Yqh+) and infertility, C-band heteromorphism of Y chromosome was quantitatively studied in 220 cases of infertile males, normal males and males from 8 families carrying Yqh+. Relative length ratios of Yqh/16p were measured and compared by a computerized micro-videomat system. It is indicated that the frequencies of Yqh/16p at 5 levels in infertile males group(120 cases) were similar to those in the control group(80 cases); the modes were of the 3rd level in both groups(60.83%; 60.0%); Yqh+frequencies of 4th and 5th were 15.83% and 17.50% respectively; all were not significantly different. The Yqh/16p of 20 cases from 8 families carrying Yqh+ showed also Yqh+(4th and 5th levels). They were all fertile (except Yqh+ proband with infertility). In infertile males, there were no positive correlation between Yqh+ frequencies and phenotypes in terms of the size of testis, azoospermia and oligozoospermia. Yqh+ frequencies between abnormality and normal karyotype in infertile males were not significantly different, either. These data suggest that there is no significant correlation between large Y chromosome(Yqh+) and male infertility. Yqh+ may be one of the hereditary characters in individuals or families.更多还原