【摘要】 <正> 复方甲地孕酮微囊注射液为本校制药厂研制的一种缓慢释放长效避孕注射剂。避孕有效率达99.1%,对其安全性曾作过一些临床研究,未发现有害效应。为探索该药是否改变细胞的诱变环境和遗传影响,作者对使用此注射剂的65例妇女,进行了外周血淋巴细胞染色体畸变率、姊妹染色单体互换率(sister chromatid exchanges,SCE)和银染核仁形成更多还原

【Abstract】 "Injectable microencapsulated compound megestrol acetate" is a monthly injected contraceptive. A study was carried out to determine its effects on chromosomal aberration, sister chromatid exchange(SCE) and silver stained nucleolar organizer region(Ag-NOR) of peripheral lymphocytes in women. The subjects were divided into two groups. In group 1, the samples were collected from 25 women before and after injection of the contraceptive. In group 2, the samples were drown from 20 women after the injection and from 20 female controls who had never been exposed to contraceptives.There was no significant change in chromosomal aberration and SCE in the two groups. The increased frequency of Ag-NOR was significant in women after the injection in group 1 and group 2. The results showed that the monthly injectable contraceptive might increase the number of active rRNA gene but not the satellite asso ciation. The authors suggested that the drug be very likely not deterimental to DNA.更多还原