【摘要】 <正> 11α-羟基-16α、17α-环氧-△~4-孕甾烯-3,20-二酮(Ⅱ)是合成可的松、强的松、肤轻松等甾体激素药物的重要中间体,由16α,17α-环氧-△~4-孕甾烯-3,20-二酮(Ⅰ)经霉菌氧化而得。上海工业微生物研究所从400余株野生梨的霉菌中,选出一株根霉80322新菌株,可在2％底物投料浓度,37℃发酵36～48h,使转化率达到55％以上,其主要发酵产物除11α-羟基-16更多还原

【Abstract】 With transformation of 16α,17α-oxido-△~4-pregnene-3,20-dione(Ⅰ)bymicroorganism Rhizopus 80322 6β,11α-dihydroxy-16,17-oxido-△~4-pregnene-3,20-dione(Ⅲ)was obtained as a by-product in addition to the main product ??11α-hydroxy-16α,17α-oxido-△~4-pregnene-3,20-dione(Ⅱ).Compound Ⅲ wasidentified by IR,UV,~1H-NMR,MS,molecular rotation difference and oxidationof itself to the known compoumd Ⅳ.更多还原