【摘要】 <正> 产黄青霉(Penicillium chrysogenum)在生物合成青霉素时,受到工业生产中无法避免的铁的干扰。其干扰程度随着培养基中铁的浓度增加而加强,球状菌株也不例外.由于青霉素球状菌株发酵液中含有大量坚韧更多还原

【Abstract】 It is well known that excess amount of iron in the fermentation broth exertsa toxic effect on the biosynthesis of penicillin and may decrease the fermentationyield."Masking" conception was applied,and three groups of compounds wereselected from a series of organic compounds containing acetic acid or sulfonicacid groups,which would cast no influence on the development and metabolismof mould and could eliminate the toxic effect of excess iron in biosynthesis ofpenicillin,so as to restore the fermentation yield to the normal level.更多还原