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前列腺素E2对四氧嘧啶所致糖尿病大鼠及正常大鼠糖代谢作用的初步观察

EFFECTS OF PGE2 ON CARBOHYDRATE METABOLISM IN ALLOXAN-INDUCED DIABETIC AND NORMAL RATS

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【作者】 刘俊平吕文赏张学春王连富宋国培王健姜薇李波叶维法傅长春张雄吉金永男

【Author】 Liu Junping et alDepartment of Medicine, The First Teaching Hospital, Bethune Medical University

【机构】 白求恩医科大学第一临床学院内分泌科白求恩医科大学第一临床学院病理科白求恩医科大学第一临床学院病理科

【摘要】 本文报告了PGE2对Alloxan所致糖尿病大鼠及对正常大鼠血糖、胰岛素和胰升血糖素的影响。结果表明:PGE2对正常大鼠和糖尿病大鼠均有降低血糖作用,对胰岛素的分泌有抑制作用,对胰升血糖素有刺激分泌的趋势。PGE2对糖尿病大鼠的降血糖作用似乎有剂量依赖性。PGE2降血糖作用可能与短暂性高血糖和抑制胰升血糖素的肝糖原分解作用有关。

【Abstract】 The effects of PGE2 on glucose metabolism in alloxan-induced diabetic and normal rats were studied by subcutaneous injection of PGE2, with the serum levels of glucose, insulin and glucagon, and histopathological survey of pancreas as indices of assessment. The results revealed that the cytoprotective effect of PGE2 against the damage of pancreatic islets caused by alloxan was invisible, however, a slight reduction of serum glucose level, suppression of insulin secretion and stimulation of glucagon secretion were observed. The hypoglycemic effect of PGE2 in alloxan-induced diabetic rats seemed to be dosage dependent and probably related to temporary hyperglycemia and inhibiton of glucagon on glycogenolysis in liver. Thus, it might be suggested that PGE2 has no cytoprotective effect on pancreatic islets against alloxan damage, but is rather an important factor in regulating insulin and glucagon secretion as well as serum glucose level both in normal and alloxan-induced diabetic rats.

  • 【文献出处】 中华内分泌代谢杂志 ,Chinese Journal of Endocrinology and Metabolism , 编辑部邮箱 ,1986年04期
  • 【被引频次】1
  • 【下载频次】20
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