【摘要】 本文报道39例胰岛素依赖型糖尿病患者经胰岛移植后已随访6月以上(6.5～32月,平均18.93±8.42月)临床研究资料。应用经短期培养的人胎胰胰岛作腹膜腔内或腹直肌内移植后1例无效,38例有效。有效者每日胰岛素用量于移植后比移植前平均减少61.34％,血糖控制显著改善,3例已分别完全停用胰岛素治疗9月、6月与1月许,空腹血清C肽浓度正常,病情控制良好;另2例曾短期停用胰岛素。38例有效患者于移植后未常规应用免疫抑制治疗而移植物功能均仍保持良好,无1例发生排斥反应。更多还原

【Abstract】 Of 39 patients with IDDM who had been grafted with 1-2-wk cultured islet tissure of human fetal pancreas, 38 cases were proved to be successful and 1 ineffective. Following transplantation, the average daily insulin requirements and average fasting plasma glucose concentrations of the 38 recipients dropped from 46.97±13.63 u and 207.03±72.92 mg/dl to 18.16±9.08 u, (p<0.001) and 161.07±57.03 mg/dl, (p<0.01) respectively. What is more, insulin treatment completely withdrawn in 3 cases for ever 9 mo, 6 mo and 1 mo respectively, and yet their fasting serum C-peptide levels were all normal and they have been remaining non-insulin dependent ever since. Two other diabetics had ever been non-insulin dependent over a period of time, too. In 9 cases the average fasting seurm G-peptide levels rose from 0.046±0.017 pmol/ml preoperatively to 0.108±0.055 pmol/ml post-operatively (p<0.01). The latest average fasting serum C-peptide levels of 25 other were 0.182 ± 0.071 pmol/ml, though the assays were undone prior to transplantation. 38 recipients have been followed up for 18.93±8.42 mo, and the islet allografts have been functioning well without any rejections.更多还原