【摘要】 本文报导了在大白鼠身上观察“H-73-10”促排铍的效果.大鼠肌肉注射硫酸铍染毒后,经由腹腔注入“H-73-10”,收集24小时尿,用原子吸收分光光度法测定尿铍含量,以生理盐水为对照,并与喹胺酸和CaNa₃-DTPA促排效果作比较.实验结果表明“H-73-10”对大鼠急性铍中毒和亚急性染毒后带铍状态,均有自尿中促排铍的作用,排铍效果优于喹胺酸;CaNa₃-DTPA则无排铍作用.染毒后即刻用药效果最好;4小时后给药则稍差.此外,观察了不同剂量和不同途径给药对排铍的影响,也观察了铍肌肉注射后经尿自然排出的规律,并与静脉注入后尿铍排出规律作了比较.更多还原

【Abstract】 This paper reports the effect of eliminating beryllium by a new chela- ting agent "H-73-10" on rats. Rats were intoxicated with BeSO₄ intramuscularly, and then injected with "H-73-10" intraperitoneally and through other routes. Twenty-four hours urine samples were collected and their beryllium contents were determined by atomic absorption spectrophotometry. Normal saline was as control and CaNa₃-DTPA and quinamic acid were used as comparison. "H-73-10" had more effect on both acute and chronic beryllium poisoning than quinamic acid did. Ca-Na₃-DTPA had no effect on beryllium poisoning elimination. Beryllium elimination was greatest among those rats that received "H-73-10"immediately after intoxication. The effects of different dosage and different routes of administration of "H-7 3-10" on beryllium elimination were examined. After exposure of beryllium by IM. the natural elimination was also observed, and compared with the elimination by IV.更多还原