【摘要】 通过山羊失血性休克复苏后并发感染的方法,复制出一种较接近战伤实际的ARDS动物实验模型。结果提示:单纯失血性休克早期复苏成功后,如果不并发感染,很少出现急性呼吸功能衰竭。更多还原

【Abstract】 Twenty-four hybrid goats were randomly divided into two groups. The animals in the experimental group(n=14)were given continuous intravenous infusion of E. Coli endotoxin(lug/kg/hr) over 8 hrs after resuscitation of hemorrhagic shock, while those in the control group(n=10) received the same treatment except E. Coli endotoxin infusion. It was shown that the mean pulmonary artery pressure in the experimental group was continuously elevated during endotoxin infusion, the leukocyte count rapidly and markedly decreased, arterial oxygen tension dropped markedly. The parameters mentioned above were not changed in the control group. Twelve animals in the experimental group died in 24 hrs, while all the animals in the control group survived. There was significant difference in wet to dry weight ratios of the bloodless lung. Light microscopic observation on the lung in experimental animals showed local hemorrhage, interstitial edema and leukostasis, and some intraalveolar space was filled with the fluid.更多还原