【摘要】 以DCC 7点Scatchard作图法测定23例胃癌组织中的ER含量,发现6例ER阳性(26.1％),其中男病人16例有4例阳性,女病人7例有2例阳性,ER水平22.5-117.3fmole/mg蛋白/ml胞液,ER阳性的病例皆属低分化细胞型肿瘤。经实验证明本组胃癌测到的ER与乳腺癌的ER的生物学特异性一致。作者从胎儿胃及其他有些脏器中测到ER的存在,更进一步支持非靶器官肿瘤中存在ER是胎儿产生激素基因重现的推论。至于胃癌中ER阳性是否有指导治疗意义,尚有待进一步研究。更多还原

【Abstract】 DCC 7 points Scatchard analysis of estrogen receptor in cytosols of 23 cases of gastric cancer disclosed ER positive in 6 cases (26.1%). Of 16 male patients ER was positive in 4 and of 7 female patients ER positive in 2. The ER level in these positive cases were 22.5-117.3 femtomoles/mg protein/ml cytosol, all of positive cases were of the undifferentiated type. The biologic properties of ER in gastric can-cer tissue appeared to be the same as those in breast cancer. Authors found that cer-tain fetus organs also contain detectable level of ER. These findings lend support to the inference that presence of tumors of nontarget organs reflects fetus-gene being capable of producing the hormone. As to application of these findings to an anties-trogenic therapy awaits further study.更多还原