【摘要】 2/3肝叶切除18-24小时后喂以DEN,能启动形成较多的癌前变异病灶,除考虑细胞s期较易形成变异细胞外,尚应考虑肝叶切除诱发小叶周边较幼稚肝细胞增生时比小叶内分化成熟细胞受致癌物质的启动更易形成变异细胞。透明细胞是严重代谢障碍的现象,它们多趋向退行性变,所以不一定是癌前性质的细胞。更多还原

【Abstract】 The initiating action of diethylnitrosamine on liver cell carcinogenesis was ac-celerated by the cell proliferation following 2/3 partial hepatectomy. The fact that DNA is liable to be injured by carcinogens and that the mutant DNA is ready to be replicated in S phase of cell cycle as suggested by others, we presume that the peri-pheral lobular immature liver cells evoked to proliferation by partial hepatectomy are more prone to tumorigenesis by DEN than that of the mature liver cells in other part of the lobules. Since some of the clear liver cells are apt to fatty or hydroptic changes, it is possible that these altered cells tend to degeneration due to its enzyme deficiency rather than neoplastic transformation.更多还原