【摘要】 本文在紫外分光光度法对多组份复方制剂的含量测定基础上,为使测定快速、准确、简便,提出了最小二乘面积拟合测定方法。先在一定成长范围内把混合物各组份标准光谱下的面积配之以一定的比例系数,用这些系数和各组份标准光谱的面积相乘的总和去近似地拟合实测混合物的光谱面积。用最小二乘法求得一组最佳比例系数值,从而求出各单一组份的含量。在整个测定过程中,利用微机进行了数据处理。对复方新诺明、复嘧啶及息痛片中各组份测定结果表明:其平均回收率均在100.0±1.0%之间,标准差均<0.02。更多还原

【Abstract】 A new rapid,simple analytical method was applied to UV spectropho tometry of the multicomponent complex preparations without previous se paration.The area of each component of the complex preparation within a suitable wavelength range of standard spectrogram was multiplied by some certain coefficients and then the products were obtained together so as to fit the area of the measured multicomponent complex preparations.The optimum cofficients may be obtained by the least spuares method.0.1 N NaOH and 0.1 N H₂SO₄ were used as sol ents to determine Sulfamethoxazole compound tablets（SMZ,TMP）.Sulfamethoxdlzine compound tablets （SMD,TMP）and Xitong tablets（Amidoprine,Paracetamol,Caffeine,Phenobarbital）,respecti ely.The experimental data were measured andtreated by using UV-300 spectrophotometer and microcomputer Apple-Ⅱseparately.The a erage recovery of each component determined was within 100±1.0% and the standard de（?）iation was less then 0.02.更多还原