【摘要】 <正> 应用免疫组织化学方法研究甲状腺组织激素的定位,对于探讨正常或病理情况下甲状腺组织产生、分泌激素的功能状态很有帮助。近几年来用免疫组织化学 PAP 法观察动物或人体病理状态下甲状腺激素的细胞学定位陆续有报导。本文应用 PAP 法观察地方性甲状腺肿组织内甲状腺球蛋白（Tg）、甲状腺素（T₄）、三碘甲腺原氨酸（T₃）和3,3′,5′-三碘甲腺原氨酸（rT₃）的细胞学定位,以探讨地方性甲状腺肿各组织学类型的激素功能状态。更多还原

【Abstract】 Endemic goiter was studied on 65cases for Tg,T4,T3 and rever-se T3 （rT3） in goitrous tissues byimmunohistochemical PAP method.The results were assessed as follows:1)in diffuse goiter,Tg,T4 and T3 werepositive in most areas;2) colloidretention nodules showed positiveTg,T₄ staining,but T₃ was nega-tive in most cases;3) Most of theadenomatous nodules showed positi-ve Tg—T₄ & T₃ being in less inten-sity.The embryonal & atypicalnodules showed positive Tg in somefoci in which tumor tissue had ten-dency of or abortive follicle form-ation;4) in most cases the stain-ing reaction of the goitrous tissuewas not uniform and less intense incolloid than that in the follicularcells;5) in most cases T3 waspositive while much more cases show-ed negative T4.Reaction for rT3was not remarkable.The above findings suggest thatmost of the thyroid nodules,irres-pective of the histological types,were hormonal functioning exceptthat in the immature cellular types.The predominance of T₃ positivetissues may be suggested as in compen-sating for iodine deficiency,thesequence of thyroid hormone pro-duction might be changed with theresult that T₃ secretion increasedmuch more than that of T4.This is inaccordance with the increase in se-rum T3 level in cases of iodine defi-ciency goiter.更多还原