【摘要】 <正> 急性咽结合膜热(Acute pharyngo conjunctival Fever)是病毒引起的眼结合膜和咽炎的急性传染病和综合症。早年的病原学研究表明腺病毒3、7、8和14型为该病的主要病因。近年又发现肠道病毒70型(小 RNA 病毒)可引起急性出血性结合膜炎。本文报导我们对1984年8月在北京市朝阳区小学生中急性咽结合膜热暴发流行进行病原学研究的结果。我们从这次累及四千多人的流行中,分离鉴定出14株7型腺病毒、并通过临床和血清学研究,确定了所分离的7型腺病毒为本次流行的病因。更多还原

【Abstract】 An outbreak of acute pharyngo conjunctival fever occured in a district of Beijing China,in August of 1984.Over 4,000 Pre-school and school children(aged6to13)were affected,and over 80% of the Patients had a history of swiming.Clinically,the illness was characterized by higd fever (39.5-41℃),pharyngitis,conjunctivitis,headache often associated with vomiting.20 samples(10 eye secretions and 10 throat swabs)from 10 patients with typical clinical signs of the illness were collected for virus isolation.14 strains of adenovirus were isolated by means of monolayer cultures of human embryonic kidney cells.Of the 14 isolates,10 were from throat(positive rate 100%)and 4were from eye secretions(40%).The virus showed a typical morphology of adenovirus in thin section electron microscopy and all 14 isolates were identified to be adenovirus type 7 by neutralization test.Therefore,the adenovirus7 was incriminated to be causative agent of the large scale outbreak of acute pharyngo conjunctival fever via water transmision as all paired sera showed more than 4-fold rise of neutralization antibody exclusively for adenovirus type 7.更多还原