【摘要】 本文报道硝基呋喃乙烯基-1,3,4-噁二唑及其酮类衍生物44个的合成。关键中间体α-取代β-（5-硝基呋喃基-2）丙烯酰彤魄仿照文献已知方法制备的,然后分别与光气或溴化腈作用生成相应的1,3,4-噁二唑衍生物Ⅰ,Ⅱ。经感染日本血吸虫病小白鼠的预防和治疗试验,发现化合物Ⅰ₁具有显著的抗血吸虫作用,并试用于家犬的血吸虫病,证明有一定的疗效。但效果不及呋喃丙胺,故未作临床观察。更多还原

【Abstract】 Forty-four compounds of nitrofuranvinyl-1,3,4-oxadiazol-2-one and its 1,3,4-oxadiazole have been synthesized. The key intermediate, α-substituted 5-nitro-2-furylacryloylhydrazine, was prepared by known method and it reacted subsequently with phosgen or bromocyanogen to form the corresponding 1,3,4-oxadiazolone of compound Ⅰ and Ⅱ respectively.更多还原