【摘要】 <正> 前列腺素E₁（简称PGE₁）的独特药理功能日益引起国际上的重视,近年来发现PGE₁在防治心血管疾病方面有突出的效能,扩张末梢血管,增加血流量,因此对慢性动脉闭塞症患者有活血作用;还能抑制血小板凝集,可防止血栓形成,预防动脉硬化;并能阻止颅内出血而引起的脑血管萎缩;在抑制溃疡病方面也有特殊作用。日本已将PGE₁制成商品,作为治更多还原

【Abstract】 This paper reports a two step synthesis of prostaglandin E₁, that is （1） Oxidation of eicosatrienoic acid methyl ester with singlet oxygen and （2） potassium borohydride reduction. Finally, the product PGE₁ was separated by rotating thin layer chromatorgraphy on silica gel with a total yield about 5.8%. The data of IR, MS and NMR are the same as those in the literature.更多还原