【摘要】 <正> 硒是人体内必需的微量元素。近年硒与心血管疾病的关系逐渐引起重视。硒缺乏与某些心血管疾病如克山病、心肌梗塞、充血性心肌病等的发病有关。硒制剂已用于临床预防和治疗某些心血管疾病。已有研究表明:亚硒酸钠有抗心律失常等药理作用;适量的亚硒酸钠可使心肌细胞动作电位时程和不应期延长。但从细胞电生理水平研究硒对心脏自发更多还原

【Abstract】 Effects of Na₂Seo₃ on the spontaneous electric activity in guinea pig ventricular muscle induced by BaCl₂ and on the rabbit sinoatrial node were observed using glass microelectrode technique. The results showed that addition of 0.6mM Na₂Seo₃ caused the barium-induced spontaneous electric activity in ventricular muscle to decrease or disappear. When sinoatrial node cells were exposed to 0.9mM Na₂Seo₃, their APA, SPo and SP₄ decreased and APD₉0, SCL were prolonged. While, when the concentration of Na₂Seo₃ was increased to 1.2raM, the AP of sinoatrial node cells disappeared. The results indicate that Na₂Seo₃ may suppress the spontaneous electric activity.更多还原