【摘要】 <正> 雪莲是菊科青木香属多年生草本植物。古籍记载,有除寒、状阳、调经、止血等作用。近年研究证明雪莲煎剂有抗炎、加强蟾蜍心肌收缩力、降低兔血压、抑制兔回肠活动、兴奋离体和在体兔子宫、终止小鼠和家兔早期妊娠等作用。我院化学教研室从雪南省德钦县产的水母雪莲花（Saussurea medusa Maxim.）中分离出多糖单一组分,已证明对小鼠有明显的终止妊娠作用。本文研究了雪莲多糖（简称SPS）对各期离体大鼠子宫的作用。并观察前列腺素E₂（PGE₂）和消炎痛对雪莲多糖兴奋子宫作用的影响。更多还原

【Abstract】 The present paper reports the effects of Saussurea Polysaccharide （SPS） on the isolated rat uterus. SPS showed stimulating effects on the isolated rat uterus at every stage of sexual cycle. After administration of SPS, the amplitude, frequency and tonus of the uterus contraction were increased immediately and significantly. The effects were more obvious on oestrous uteri. The potency and duration of action of SPS were dose-dependent. The stimulating effects of SPS on uteri were potentiated by PGE₂ and decreased by indomethacin. It is possible that the mechanisms of SPS action may be due to its direct effect on the uterine smooth muscle or its promotive effect on PGs synthesis in the uteri.更多还原