【摘要】 碘杂环-64能防治乌头碱、氯化钡和结扎冠状动脉诱发的大鼠心律失常,推迟肾上腺素—氯仿诱发家兔心律失常的发作和缩短心律失常持续期,提高哇巴因诱发豚鼠心律失常的剂量,显著降低乙酰胆碱(Ach)—氯化钙诱发小鼠房颤(扑)的发生率。碘杂环-64减慢心率与迷走神经兴奋和β受体阻滞无关。更多还原

【Abstract】 The antiarrhythmic effects of iodium-heterocycle-64 were reported in this paper. IHC-64 ⅳ 2～4 mg/kg decreased significantly the incidence of aconitineinduced arrhythmias in ratsand Ach-CaCl₂-induced artrial fibrillation（flutter）in mice, delayed the onset and shortened the duration of adrenaline-chloroform-induced arrhythmias in rabbits. The drug also increased markedly the ouabain dose to cause ventricular premature beats, ventricular fibrillation and cardiac arrest in guinea-pigs, and made BaCl₂-induced arrhythmias in rats restore immediately into sinus rhythm with the duration of more than 10 min. The incidence of ventricular tachycardia and ventricular fibrillation yielded by left coronary ligation in rats declined significantly by ⅳ IHC-64 4 mg/kg 10 min before and 2 mg/kg immediately after ligation. IHC-64 produced a bradycardia even after vagotomy, and did not block the isoprenaline-induced tachycardia and hypotention in rats.更多还原