【摘要】 测定精神分裂症患者32例与正常对照组22例在子夜0时和上午8时的血浆 TSH 水平,结果显示患病组比对照组 TSH 均值明显增高,患病组 TSH 的昼夜节律颠倒,8时反比0时血浆 TSH 均值高。推测其原因可能与患者脑部多巴胺系统和5-HT 系统之间不平衡有关。更多还原

【Abstract】 Measurements of plasma thyroid-stimulating hormone at midnight and 8 AM in 32 cases of schizophrenia treated with chlorpromazine hydrochloride were reported.The resu- lts were compared with that of 22 normal controls. The mean values of plasma TSH of the patients both at midnight and 8 AM were much greater than that of normal controls.Furthermore,the diurnal rhythm of TSH in schizophrenic patients was reversed,that the mean value of plasma TSH at 8 AM was greater than that at midnight. The above changes might be related to the disturbance of balance between dopamine and 5-hydroxy-tryptamine(5-HT)systems in the brain of schizophrenic patients,and the effect of chlorpromazine,if any,probably would be very slight.更多还原