【摘要】 对310例HBsAg携带者的e系统经2.5～6年(平均4.2年)的追踪观察结果表明,85例e 抗原阳性者中66人阴转(占77.6%),平均每年自然阴转率为18.5%,其中从e 抗原向e 抗体的血清转换占20%。44例e 抗体阳性者中有52.3%的人阴转,有1例(占2.3%)向e 抗原逆转,同时肝炎急性发作。181例e 系统阴性者有86.2%仍阴性,11.6%出现抗体。e 抗原阴阳交迭现象,在e 抗原阳性者中占18.8%(16/85),在e 系统阴性者中占7.7%(14/181),两者有非常显著性差别。影响e 抗原阴转的因素有时间,性别与HBsAg 滴度。更多还原

【Abstract】 A follow-up study on HBeAg and Anti-HBe system was carried out among 310 HBsAgcarriers for 2.5-6 years (average 4.2 years).The results were as follows;66 out of 85cases who had been HBeAg positive became negative,i.e.77.6% with an annual negative-conversion rate of 18.5% and the serum conversion rate from HBeAg to anti-HBe was20%.44 anti-HBe positive patients had their negative-conversion rate of 52.3%,but in 1 (2.3%) had reconversion from anti-HBe to HBeAg happened and an acute exacerbationof hepatitis had occured in this patient.Among 181 persons negative for both HBeAgand anti-HBe,156 remained the same (86.2%),but anti-HBe appeared in 21(11.6%).The alternative appearance of HBeAg in either direction(+(?)-)was found to be 18.8%(16/85) in the HBeAg positive persons and 7.7% (14/181) in e system negative ones.Thedifference was very significant.The HBeAg negative-conversion would be varied withfactors of time and HBsAg titres,similar to those foreign reports.更多还原