【摘要】 已知潘生丁在三种鼠细胞和人二倍体肺成纤维细胞、以及小鼠体内(静脉注射)能诱生干扰素。1984年,我们研究潘生丁在人脐血白细胞内和志愿者体内诱生干扰素活性。结果表明,20～600μmol 浓度的潘生丁有明显诱生活性,这种活性有剂量依存关系,最适干扰素诱生浓度为100μmol。在体内,给成人志愿者一次口服100mg(1.7mg/kg)潘生丁,12h 后血内干扰素水平达高峰(68IU/ml)。根据pH 稳定性和热稳定性试验结果,初步认为潘生丁诱生的干扰素为Ⅰ型干扰素。更多还原

【Abstract】 It was known that Pyrimidine induced interferon production inmice after intravenous administration,and in vitro on 3 cellularmodels from mice,as well as in human diploidembryolung fibroblasts.In 1984,we have tested the interferon-inducing ability of pyrimidinein leukocytes of human umbilical cord blood,as well as in thevolunteers after oral administration.The results show that pyrimidinehave marked interferon-inducing effect at concentration of 20～600 μmol.It is strongly dose dependent.The optimal interferon-inducingconcentration is 100 μ mol.In adult,Pyrimidine given a singledose of 100mg(1.7mg/kg)per Os,a peak blood interferon(68IU/ml.)reached in 12h.It is suggested that the type of induced inter-feron seems to be Type I.更多还原