【摘要】 Malotilate（50或100mg/kg ig×3）可明显对抗四氯化碳（CCl₄）引起的小鼠血清转氨酶升高、肝糖元合成减少、肝脏蛋白质及血清蛋白质含量降低、肝脏甘油三酯蓄积以及肝匀浆细胞色素P-450含量降低,使之恢复或趋于正常水平。malotilate（50mg/kg ip×5）亦可明显对抗D-半乳糖胺引起的SGPT的升高和肝脏蛋白含量的降低。更多还原

【Abstract】 A study was made; of the effect of malotilate on the acute liver injury induced by carbon tetrachlorid,e ( CC14 ) and d-galactosamine in mice. Malotilate ( 50~150mg/kg ig×3 ) significantly inhibited the elevation of serum glu tamic pyruvic transaminase ( SGPT ) in CC14- intoxicated mice.At the dose of 100mg/kg ig×3, malotilate remarkably increased the content of hepatic glycogea in CCl4-injected mice. The contents of serum protein, liver protein, and cytochrom P-450 in liver hemogenate were increased by malotilate ( 100mg/kg ig×3) in CC14-intoxicated mice. The drug also reduced the accumulation of liver triglycerides induced by CCl4 in mice.In addition to, malotilate(50mg /kg, ip×5) could act against the increase of SGPT and the decrease of liver protein content induced with d-galactosamine in mice. These results suggest that malotilate may be a new therapeutic agent for liver injury.更多还原