【摘要】 本文采用氯仿萃取血清中甲硝哒唑,自氯仿中转溶于0.1N Hcl中,于277nm外测定吸收值;当甲硝哒唑浓度在2～50μg间,有良好的线性关系（r=0.9999,n=7）,家兔50mg/kg一次灌胃,测得t_峰=1.5小时,C_Max=8μg/ml;患者口服0.4g,t.i.d稳态后,晨间C_Min=12.14±3.14μg/ml,C_Max=27μg/ml。更多还原

【Abstract】 We developed a simple method for measuring metronidazole in serum. The me-tornidazole in scrum was extracted with chloroform and redissolved in 0.1 N HCl. Its quantitation was based on spectrophotometry at 277 nm. when serum level was 2-50 ng, there existed a linear relation between absorption and metronidazole level (r= 0.9999,n= 7). After giving rabbits metronidazole 50mg/kg by stomach tube,theplasma concentrations of the drug showed Cmax =8 ug/ml and Th =1.5 hr, andapproached O in the 7th hour. In patients, whose blood level had reached a steady state after metronidazole 0.4 g tid for several days, their Cmin = 12.4 ± 3.14 ug/mlin the morning and the Cmax =26-27 μg/ml after oral intake. These results con-firm that metronidazole does not accumulate in the body.更多还原