【摘要】 本文选用Ames、大肠杆菌回变和枯草杆茵重组等三种细菌诱变试验系统,检测乐果的突变性,结果均为阴性,但微核试验获得阳性结果。且有明显的剂量效应关系,提示,乐果与白血病的关系,似有进一步研究的必要。更多还原

【Abstract】 Four among eight peasants who had leukemia had had a history of acute dimethoate poisoning were acidentally found, this led to the present study.Negative results obtained in the 3 selected bacterial mutagenicity test systems, including: Samonella microsomal test and E. coli reverson test, both representing gene mutation; and B. subtilis rec-assay which representing primary DNA damage and repair.Positive result obtained in micronucleus test, in which 615 inbred mice were used, 16 per group, 0, 10, 20, 40 mg/kg pure dimethoate (dissolved in water) were injected subcutaneously, once a day for 5 days. Mean of the micronucleated polychromatic erythrocyte count were 3.9±0.91, 7.81±2.01, 8.81±2.10, 11.78±2.46‰ respectively, all treated groups were very significantly higher than the untreated group (p<0.01) and clear dose-effect relationship were demonstrated.The author stress that the relationship between dimethoate and leukemia worth for further investigation.更多还原