【摘要】 本文应用GC-RIA（岛津）气相色谱仪,分析了8只健康家兔在接受苦杏仁甙（Ⅰ）后的血药浓度,绘制药-时曲线,求生物半减期（（?）±SD）,t_1/（2α）（分布相）=38±4min,t_1/（2β）（消除相）=77±18min。（Ⅰ）对正常小鼠毒性实验提示（Ⅰ）引起中毒的主要因素,除了与用药剂量大小有关外,与用药途径的关系更为重要。剂量相同条件下,非胃肠道给药（静注）较之胃肠道给药安全得多。1例食管癌病人用苦杏仁甙治疗,对用药后血、尿进行检测。更多还原

【Abstract】 Amygdalin (500mg/kg) was injected intravenously to 8 rabbits. The plasma concentration of the drug was measured by gas chromatography.From the concentration-time curve the phar-macokinetic parameters were calculated; t = 38 ± SD 4 min , and t, = 77 ± 18 min.Experiments on mice revealed that the cyanides toxicity was closely related to the dose and the route of administration.The same dose(500mg/kg)was given to mice. A comparison of the toxicity of drug given intravenously with that given orally in mice showed that the intravenous route of administration did indeed result in 100% survival without any toxicity, but oral route of administration were only 20% survival.The dosedecreased to 300 mg/kg, 40% survival.Amygdalin concentrations in blood and urine of a patient with esophageal carcinoma were also determined.Amygdalin was administered by intravenous infusion (6 g/3 h) then, the plasma and urine were measured by gas chromatography, respectively.Neither sample was responses, but when the amygdalinzyme was additional, respectively. Both sample were response. The amygdalin concentration was 0.0776 mg/kg in plasma and 3.4477 mg/kg in urine.更多还原