【摘要】 黑白花奶牛164头计415个乳区按CMT或HMT等级分为阳性治疗试验(++、+++)、阳性治疗对照(++、+++)、阴性空白对照(-、T、+)三组。第一组系用长效抗菌素油剂(TA—125)10毫升分别于干奶前三天及干奶当天注入乳区;“+”以下乳区不作处理;或在炎热季节于干奶当天将20毫升TA—125一次注。入,同时对“+”以下乳区各注入10毫升。通过HMT、菌检及临床检查证明:阳性治疗试验组的总有效率为95.5％,总转阴率48.2％,与阳性治疗对照组差异非常显著(P<0.01)。阴性对照组在产后仅有33.3％为阴性,并有39.0％的乳区发生新感染。阳性治疗试验组产后隐性乳房炎(++、+++)和细菌检出率显著低于干奶前(P<0.01),且在干奶期间及产后二周内的临床发病率也明显低于对照组(P<0.01)。从而证实TA—125能有效地防治干奶期葡萄球菌、链球菌性乳房炎和泌乳期遗留下来的隐性乳房炎。 155个阳性治疗试验组乳区干奶前的菌检率为82.6％,产后一周降为35.5％,二周则又回升至45.8％,说明干奶期乳房炎的防治单靠药物不行,必须重视科学管理,加强和改善卫生条件,否则可重新感染。 TA—125是氯苯唑青霉素钠和苄星青霉素的油剂,冰箱中可保存一年。产后一周的牛奶中无青霉素残留。更多还原

【Abstract】 This experiment, involving 164 cows with 415 quarters, comprised one treated trial group with 155 HMT ( Hangzhou Mastitis Test ) high graded quarters ( ++, +++ ) , one treated control group with 83 positive ones(++, +++ )?and one control group with 177 negative and an untreated weak positive group (-,T,+ ) . In 1982-1983, only the positive quarters (+ + , + + +) of the trial group were treated with a long acting antibiotic preparation ( TA-125 ) in a dose of 10ml three days before and on the day of drying off respectively. During the summer months of 1984, all the trial quarters were treated with TA-125, 20ml for "++, +++" quarters and 10ml for "-,T,+" ones once on the day of drying off. According to CMT or HMT, bacteriological and clinical examinations, the trial group showed a total effective rate of 95.5%, and the total negative conversion rate of 79.4% of the treated quarters, compared with the effective rate of 77.1% and the negative conversion rate of 48.2% in the control group treated with penicillin and streptomycin preparations.The statistical difference betw.een them is marked significant ( P< 0.01 ).Only 33.3% of the untreated control quarters remained negative and the rate of new infection after calving was 39%. A comparison in CMT or HMT grade and in the percentage of pathogens positive isolation of pathogens made in the TA-125 treated group before drying off and after calving, also showed a marked significance ( P<0.01 ) . Incidence of clinical mastitis in the trial group was significantly lower than that of the control groups during the dry period and two weeks after calving ( P<0.01 ) .It is concluded that TA-125 was effective in the prevention and treatment of staphylococcal and streptococcal mastitis in dry cows and subclinical mastitis left over from the lactation period.Organisms were isolated from 82.6% quarters in the trial group before parturition, 35.5% and 45.8% at one and two weeks after calving respectively. This indicates that scientific management, teat disinfection after milking and improvement of hygiene are very important in the control program of bovine mastitis.TA-125 is an oily suspension containing Benzathine Penicillin and Sodium Cloxacillin, and its value remained unchanged after one year’s preservation in the refrigerator. There was no penicillin residue in the milk samples taken one week after calving.更多还原