【摘要】 <正> 近年来一系列资料指出:前列腺素（PG）合成或释放异常与多种心血管疾病的发生有关。前列环素（PGI₂）和血栓素 A₂（TXA₂）均来自花生四烯酸（AA）。PGI₂主要在血管内皮细胞内合成,有强烈的扩血管作用,且是最强的抑制血小板聚集的物质;TXA₂主要在血小板内合成,有强烈的缩血管和促血小板聚集作用。二者平衡是体内调节血小板更多还原

【Abstract】 Twenty normal rabbits,ten rabbits with atherosclerosis,and ten rabbits recei-ving vitamin E during formation of atherosclerosis,were included in the study.Thelevels of 6-keto PGF_1α——the product of prostaeyclin （PGI₂）,and thromboxane B₂（TXB₂）——the product of thromboxane A₂ （TXA₂） in the plasma were measured res-pectively.The results showed that the level of 6-keto-PGF_1α of the atherosclerosisgroup was decreased 57%,as compared with that of the normal group P<0.001);where as the level of TXB₂ was increased 60%,compared with that of the normalgroup （P<0.01）.The level of 6-keto-PGF_1α of the atherosclerosis plus vitamine Egroup was 110 percent higher than the atherosclerosis group,while that of TXB₂ wasdecreased 56% （P<0.01）.The levels of 6-keto-PGF_1α and TXB₂ of this group rema-ined unchanged as compared with the normal group （P>0.05）.It was suggested thatunder normal physiological condition there was a dynamic balance between PGI₂ andTXA₂,an important mechanism controlling platelets aggregation and vascular tension.Once the balance was disturbed a series of pathological changes would occur,lea-ding to atherosclerosis.Effects of application of vitamine E suggested that it isimportant to adjust the rational composition of the diet,to alter the precursor-com-ponents of PG in the food.Thus the disturbance of PG metabolism can be correctedin this way,and atherosclerosis prevented and cured.更多还原