【摘要】 <正> 1975年 Samullon 等发现前列腺素（PG）内过氧化物在血小板内能产生一种强烈的,使血管收缩和血小板聚积物质,后定名为血栓素（TXA₂）,次年 Moncada 和 Vane²又发现一个与 TXA₂作用完全相反的物质更多还原

【Abstract】 Plasma Levels of 6keto PGF₁α and TXB₂ were assayed in 40 normotensive subjects（20 males and 20 females,aged from 22 to 54,average 37±8）.Plasma levels of 6ketoPGF₁α,TXB₂ and T/P were 80.76±14.36 pg/ml,61.38±39.25 pg/ml,0.78±0.52 in men and83.34±25.59 pg/ml,76.38+44.69 pg/ml,0.90±0.50 in women respectively.There wereno significant difference in 6keto PGF₁α and TXB₂ production between females andmales.There were no definite relationship between 6keto PGF₁α,TXB₂ and PRA,ATII,serum sodium,serum potassium,serum calcium,serum uric acid.But plasma TXB₂levels in subjects with a family history of hypertension were significantly higher thanthat of in subjects without hypertensive family history （P<0.01）.Similar findingswere observed in different age groups （P<0.01）.These results indicate that T/P ismore sensible than single plasma levels of PGI₂ or TXB₂ in clinical study.更多还原