【摘要】 <正> 临床血清地高辛浓度的测定,为合理用药,预防和早期发现地高辛中毒,提供了一个有价值的方法。本文的目的是:确定口服剂量和血药浓度的关系以及年龄的影响,血清地高辛浓度和中毒反应的关系以及疾病种类的影响,并以此为基础提出对临床用药常规的一些建议。一、病例选择及方法更多还原

【Abstract】 The nature of the pathological changes in myocardium plays a more importantrole in the determination of digoxin tolerance rather than the age of a patient.Patientswith congenital heart disease tolerate higher digoxin serum levels without toxitythan patients with rheumatic carditis or congestive cardiomyopathy.It seems that di-goxin serum concentration≤3ng/ml is more likely to be save for the former and≤2ng/ml is relatively save for the latter.Oral doses and serum levels are in liner correla-tion.However,children have higher serum levels than that of the infants on a sameoral dosage(μg/kg).Based on this fact,we propose a routine digoxin dosage tokeep serum level within therapeutic range(0.5～2ng/ml)for daily practice.If the effectof digoxin treatment is not satisfactory,it is necessary to check the serum levelbefore any readjustment of the dosage.更多还原