【摘要】 <正> 在动脉粥样硬化病变发展过程中常发生血小板聚集,后者是冠心病发病机制中的一个主要环节。因此,了解动脉粥样硬化病变过程中血小板聚集的情况将有助于对冠心病更多还原

【Abstract】 A model of experimental atherosclerosis is established in 11 male rabbits by thecombination of classical method on high-cholesterol diet for 6～11 weeks and Bau-mgartner’s technic operating at the site of ascending aorta.In each rabbit,circula-ting platelet aggregation index(CAPI)by Wu and Hoak’s method is measured wee-kly before and after the performance of Baumgartner’s technic and serum choles-terol measurement in 6 of them.The rabbits are killed on varied levels of CPAIand pathological examinations are made on specimens of ascending aorta and carotidartery.Moreover,4 of these samples are also studied by electronic microscopy. The result of this study shows:(1)pletelet aggregation are found on the surfaceof the intima and degenerated pletelets are crowded beneath the intima,around thesmooth muscle cells and the fibrocytes.It indicates that platelets aggregate in theatherosclerotic plaque in the evolution of the disease.(2)CAPI is closely related todifferent stages of atherosclerosis,it declines as the illness advances.Besides,CPAI isalso inversely related to the concentration of serum cholesterol in the early stage,butit loses this relationship in the later stage.It indicates that the level of CPAI is inde-pendent of serum cholesterol concentration in the later stage of atherosclerotic pro-cess.(3)During the evolution of atherosclerosis,there are some kinds of patholo-gical changes which may be attributable to the production of platelet aggregation.They are the formation of thrombosis,exuviation of intima,prominent extrusion ofintima and narrowing of the arterial vessels.We found that these changes appearmore often when the level of CPAI is considerably low.However,beside the throm-bosis,other changes do not directly related to the extent of platelet aggregation.The result of this study agrees with clinical observations.We had previouslyshown thai CPAI levels paralled with the severity of CHD.So,both experimentalarid clinical studies show that the level of CPAI may be a good index of the se-verty of the disease.Therefore,it is reasonable to suggest that CPAI could be usedclinically to monitor CHD patients.We had also showed previously that angina pectoris at rest do have plateletaggregation,but it is not clearly known whether platelet aggregation induces theattack of angina or the former is just provoked by myocardial ischemia.The siteof experimental atherosclerotic process accompany platelet aggregation in our studyis located at the ascending aorta and carotid artery which would not lead tothe occurrence of myocardial ischemia.Therefore,our study clearly indicates thatplatelet aggregation comes before the attack of angina pectoris at rest.更多还原