【摘要】 本实验主要观察蝙蝠葛碱大、中、小剂量对大白鼠心、肝、肾及肾上腺的亚急性毒性影响。该药4.8～600mg剂量用药18天或2～3月,对心脏无不良影响。150mg以上剂量用药2～3月对肝脏有不同程度的损害,受损程度随剂量增大而加重,150mg所致的损害是轻度的,75mg以下无不良影响。300mg以上对肾有轻度损害,150mg以下对肾和肾上腺基本无不良影响。按蝙蝠葛碱的降压和抗心律失常有效量计算,该药只对肝脏有轻度损害作用。更多还原

【Abstract】 Dauricine is an alkaloid extracted from the rhizoma of menispermum dauricum DC which has been demonstrated experimentally to have hypotensive and antiarrhythmic activity. In this experiment, the subacute toxic influences of different doses of dauricine on the function and morphology of heart, liver, kidneys and suprarenal glands in rats were observed principally. There were no significant influences on the heart, after 4.8-300mg/kg a day per os for two or three months, or 600mg/kg for eighteen days. The liver or kidneys might be slightly damaged respectively with the dose 150mg/kg or 300mg/kg for three months. The intensity of damages is associated with the dose proportionally. In accordance with the clinical effective dose of dauricine, the experimental results indicated that dauricine might only inhibite the function of liver slightly. So that, it is a hypotensive and antiarrhythmic drug with small toxicity and large safety scope.更多还原