【摘要】 本实验以生理盐水分段冲洗家兔输卵管及子宫,收集孕卵并作形态学观察。结果表明,给药后24～48小时孕卵在输卵管内的运行稍有加快,以后明显减慢以致大多数孕卵滞留在输卵管内。孕卵发育受阻,其外周粘蛋白层变薄,部分孕卵出现退行性变化。以上各种改变证实炔诺酮肟的抗着床作用是干扰了孕卵的运行及发育。由于这些变化与外源性雌激素作用相似,提示在家兔实验中炔诺酮肟抗着床作用可能与它具有的雌激素活性有关。更多还原

【Abstract】 The effects of norethisterone-3-oxime(NETO)on ovum transport and developmentin rabbits were studied to evaluate the mechanism of its anti-implantation action.Segments of divided oviduct and uterus were flushed with saline and ova were collectedseparately from each segment.The morphology of the ova was studied microscopically.The results indicated that ovum transport in oviducts was slightly accelerated 24～48 hr afteradministration of NETO,and then was obviously delayed so that most of the ova were retainedin the oviduct.Ovum development was retarded.The thickness of mucin coat was reducedand some ova degenerated.These findings demostrated that the anti-implantation action of NETO was related toits interference with ovum transport and development.Because all the changes were verysimilar to those caused by exogenic estrogens,it is suggested that the anti-implantation actionof NETO in rabbit may be due to its estrogenic activity.更多还原