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门诊应用dl-15-甲基前列腺素F2α合并丙酸睾丸酮催经止孕的初步报道

FURTHER CLINICAL USE OF DL-15-METHYL-PROSTAGLANDIN F1α AND TESTOSTERONE PROPIONATE FOR TERMINATION OF EARLY PREGNANCY IN OUTPATIENT DEPARTMENT

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【作者】 周毓棻; 程利南; 干莲; 熊邦瑜; 金昭英; 郑玲妹;

【Author】 Zhou Yu-fen Cheng Li-nan Gan Lian Xiong Beng-yu (Department of Obstetrics and Gynecology,Zhong Shan Hospital,Shanghai Medical University)Jin Zhao-ying Zheng Ling-mei (Department of Pharmaceutics,Shanghai Medical University)

【机构】 上海医科大学附属中山医院妇产科; 上海医科大学药剂教研组; 上海医科大学药剂教研组;

【摘要】 在住院应用dl-15-甲基前列腺素F2a(简称15-甲PGF2a或PG)合并丙酸睾丸酮(简称丙睾)抗早孕的基础上,本组进一步简化给药方法,初步观察在门诊应用15-甲PGF2α合并丙睾催经止孕30例,对象均为停经42天以内。每天肌注丙睾100mg,共3天,第4天在阴道后穹窿置含15甲PGF2α6mg 海绵一块,6小时后肌注15甲PGF2α2mg。以血清β-hCG 判断效果,29例止孕者有27例(93.10%)完全流产,2例(6.90%)不全流产,1例催经者用药后月经来潮3天,催经止孕效果均满意,为门诊应用药物催经止孕开辟了新路。

【Abstract】 Thirty women with amenorrhea up to 42 days were treated in opd,29 were for termina-tion of early pregnancy and 1 for menstrual induction.Protocol of treatment was simplified.Testosterone propionate 100mg were injected intramuscularly daily for 3 days,followed byvaginal sponge containing 6mg of dl-15-methyl-prostaglandin F2a and then intramuscularinjection of 2mg of the same drug 6 hr later.The results of the 29 early pregnancy caseswere 27(93%) complete abortion and 2(7%)incomplete abortion.A 3-day menstruationwas induced in the non-pregnant case.With prophylactic use of fluphenazinum anddiphenoxylate compound the untoward reactions of vomiting and diarrhea were much re-duced.The opd use of dl-15-methyl-prostaglandin and testosterone propionate is consideredsafe and practical.

  • 【文献出处】 生殖与避孕 ,Reproduction & Contraception , 编辑部邮箱 ,1986年01期
  • 【被引频次】4
  • 【下载频次】15
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