【摘要】 从复方乙酰水杨酸片(APC)灼烧物中分离出六个化合物,其中五个化合物分别鉴定为阿斯匹林(Ⅰ),非那西丁(Ⅱ),水杨酸(Ⅲ),水杨酸乙酯(Ⅳ)及水杨酸苯酯(Ⅴ)。第六个化合物系苯酰苯胺衍生物,命名为 N-(4-乙氧苯基)-2-羟基苯酰胺(益肤酰胺,Ⅵ)。药理实验结果表明,化合物(Ⅰ),(Ⅴ)及 APC 片灼烧物具有明显的胃肠道蠕动抑制作用;益肤酰胺(Ⅵ)具有较强的免疫抑制作用。更多还原

【Abstract】 Six compounds were isolated from the burned ash of APC tablets.Five of them were identified as aspirin(Ⅰ),phenacetin(Ⅱ),salicylic acid(Ⅲ),ethyl salicylate(Ⅳ),and phenyl salicylate(Ⅴ)respectively.The sixth compound was a derivative of benzanilide named N-(4-Ethoxyphenyl)-2-hydroxy- benzamide(Efuamide)(Ⅵ). In pharmacological assay,aspirin and phenyl salieylate were found to inhi- bit peristalsis of the stomach and intestines in rats apparently.N-(4-Ethoxyphe- nyl)-2-hydroxybenzamide was found to have strong immunosuppressive action.更多还原