【摘要】 红细胞谷胱甘肽还原酶缺陷分原发与继发两种,继发者可由多种因素引起,核黄素（维生素乙₂）缺陷为其主要原因。本文对一例急性肾炎合并核黄素缺乏者用荧光斑点法测定了患者红细胞谷胱甘肽还原酶活性,发现在核黄素缺乏的急性期,其荧光消失时间超过一小时,而在经过核黄素治疗15天后,其荧光消失时间恢复正常,在15分钟就消失。本文还对葡萄糖6磷酸脱氢酶与谷胱甘肽还原酶的鉴别、继发性谷胱甘肽还原酶缺陷的原因、及诊断此酶的原理进行了讨论。更多还原

【Abstract】 Erythrocyte glutathione reductase(GR) deficiency is divided into two ty-pes. One is the primary type, the otheris the secondary type which is causedby many factors. Riboflavin (vit. B2)deficiency is the major cause of thelater.The activity of glutathione reduct-ase was determined with fluorescentspot test in one case of acute nephritiscomplicated with riboflavin deficiency.Fluorescence disappeared at more than 60’ during the acute phase of ribofla-vin deficiency and at 15’ (normal va-lue is within 15’) after taking vit. B-2 for 15 days.The difference between G6PD and GR deficiencies, the causes of the se-condary GR deficiency and the principle of diagnosing this enzyme were also discussed in this paper.更多还原