【摘要】 以1.2A分辨率的胰岛素精细结构模型为基础,分析并确定了三方二锌猪胰岛素晶体中二体分子的构象差异。构象差异不仅表现于侧链残基,也涉及到主链构象的变化。二体分子的构象差异带来的不对称性也明显地表现在二体分子的氢键体系和结合水的差异。局部微环境的不同是维持二体分子构象差异的稳定因素。文中对有重要差异的残基作了较详细的分析和讨论。更多还原

【Abstract】 The conformational differences between the two molecules in the dimer of insulin were determined and analysed on the basis of the structure model refined to 1.2A resolution The conformational differences were found to exist not only in side-chains but also in main-chains As the result of these conformational differences,assymmetry in distributions of hydrogen bonds and bound waters for each of the two molecules within the dimer were evident The difference in local micro environments between the two molecules was the stabilizing factor for maintaining these conformational differences Some of the important differences were analysed and discussed in this paper更多还原